Healthspan proteomic score

1. Major depressive disorder decreases healthspan proteomic score in silico (MR-IVW β = -0.02, p < 0.001).

   “HPS: MR-IVW β=-0.02, p < 0.001;”

   In silicoMendelian randomization analysis

   Causal Associations Between Major Depression and Accelerated Biological Aging. · GSA 2025 abstract · 31 Dec 2025

Major depressive disorder →

1. Healthspan proteomic score is associated with mortality in humans.

   “identify proteomic signatures of healthspan and its association with mortality and multiple age-related adverse health outcomes”

   Review

   Biomarker Insights Into Brain Health, Aging, and Healthspan · GSA 2025 abstract · 31 Dec 2025

2. Healthspan proteomic score predicts mortality in humans.

   “HPS outperformed chronological age and other biological age measures in predicting mortality and various chronic diseases.”

   Humansplasman = 53,018

   A Proteomic Signature of Healthspan · GSA 2025 abstract · 31 Dec 2025

1. Healthspan proteomic score predicts chronic disease in humans.

   “HPS outperformed chronological age and other biological age measures in predicting mortality and various chronic diseases.”

   Humansplasman = 53,018

   A Proteomic Signature of Healthspan · GSA 2025 abstract · 31 Dec 2025

Chronic disease →