Plasma protein expression

1. Essential amino acids increase plasma protein expression in humans (1.5-fold change).

   “Notably, five proteins showed a significantly higher fold change expression in the EAA group which included adenylate kinase isoenzyme 1, casein kinase II 2-alpha, Nascent polypeptide-associated complex subunit alpha, peroxiredoxin-1, and peroxiredoxin-6.”

   Human triallow physical functioning

   Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults

   GeroScience·Feb 1, 2023

More on Essential amino acids

1. Baseline frailty index is associated with plasma protein expression in humans (5 years: β 0.05–1.35; 10 years: β 0.51–1.48; all p < 0.001).

   “Increments in baseline FI consistently associated with a change in protein expression over time”

   Humansplasma5 and 10 yearsfemales

   Pro-Inflammatory Proteins Associated with Frailty and Its Progression-A Longitudinal Study in Community-Dwelling Women

   Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·May 31, 2023

1. Age is associated with plasma protein expression in humans.

   “This study demonstrated notable changes in the expression of several proteins as age increased.”

   Humanshealthy Malay adultsplasman = 160

   Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency

   Journal of Alzheimer's disease : JAD·Dec 31, 2018