Plasma %p-tau217 slope

1. Plasma %p-tau217 slope predicts Aβ accumulator status in humans.

   “Plasma %p-tau217 slope also yielded a higher AUC for Aβ accumulator status than baseline plasma %p-tau217.”

   HumansCognitively unimpaired participants with baseline Aβ-PET <40 CL; compared with baseline plasma %p-tau217

   Plasma p-tau217 for detecting Aβ-PET positivity and tracking early amyloid accumulation in cognitively unimpaired ADNI participants

   Journal of Alzheimer's disease reports·Aug 14, 2026

More on Aβ accumulator status

1. Plasma %p-tau217 slope is associated with annual Aβ-PET Centiloid increase in humans (β = 1.38; FDR-adjusted p < 0.001).

   “longitudinal plasma %p-tau217 slope was the only plasma biomarker independently associated with annual Aβ-PET CL increase in fully adjusted models (β = 1.38; FDR-adjusted p < 0.001).”

   HumansCognitively unimpaired participants with baseline Aβ-PET <40 CL; fully adjusted models

   Plasma p-tau217 for detecting Aβ-PET positivity and tracking early amyloid accumulation in cognitively unimpaired ADNI participants

   Journal of Alzheimer's disease reports·Aug 14, 2026

More on Annual Aβ-PET Centiloid increase