Annual Aβ-PET Centiloid increase

1. Plasma %p-tau217 slope is associated with annual Aβ-PET Centiloid increase in humans (β = 1.38; FDR-adjusted p < 0.001).

   “longitudinal plasma %p-tau217 slope was the only plasma biomarker independently associated with annual Aβ-PET CL increase in fully adjusted models (β = 1.38; FDR-adjusted p < 0.001).”

   HumansCognitively unimpaired participants with baseline Aβ-PET <40 CL; fully adjusted models

   Plasma p-tau217 for detecting Aβ-PET positivity and tracking early amyloid accumulation in cognitively unimpaired ADNI participants

   Journal of Alzheimer's disease reports·Aug 14, 2026

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