What does the research say about plasma lipid species?

Plasma lipid species

There are 3 papers on plasma lipid species in aging research: 3 observational studies in people. The newest story, Nov 2, 2026: “Genetic analysis links hip and thigh fat to lower liver cancer odds”.

Biomarker

3 papers study it6 more mention it5 findings

1 new paper in 30 daysSee all 9 papers on plasma lipid species

“Associations with age and sex were found for 472 (66.9%) and 583 (82.6%) lipid species, respectively.”

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studiesPLoS biology2020doi:10.1371/journal.pbio.3000870

Humans3

Associations

Age

mixedin humans2

2 studies

Age is associated with plasma lipid species in humans (147 species, 11 subclasses, 4 classes).
“Significant age associations were identified in 4 classes, 11 subclasses, 147 species”
Humansplasman = 980
Age and sex are associated with the plasma lipidome: findings from the GOLDN study
Lipids in health and diseaseApr 3, 2021
Plasma lipid species is associated with age in humans (472 (66.9%) lipid species).
“Associations with age and sex were found for 472 (66.9%) and 583 (82.6%) lipid species, respectively.”
Humansn = 10,339
High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies
PLoS biologySep 28, 2020

Sarcopenia

mixedin humans1

1 study

Plasma lipid species is associated with sarcopenia in humans (13 lipid species).
“Thirteen lipid species—primarily lysophosphatidylcholines, lysophosphatidylethanolamines, hexosylceramides, and acylcarnitines—were significantly associated with sarcopenia.”
Humans13 lipid speciesn = 40
Integrative analysis of plasma small-molecule and gut-microbiome markers of sarcopenia in a pilot study within an Indian cohort
Scientific reportsJan 17, 2026

Latest

5 papers in 12 months

Experimental Biology and MedicineNov 2

Genetic analysis links hip and thigh fat to lower liver cancer odds

In FinnGen, genetically predicted hip and thigh fat, adjusted for body size, was associated with lower liver cancer odds, with an odds ratio of 0.444.In FinnGen, genetically predicted hip and thigh fat, adjusted for body size, was associated with lower liver cancer odds, with an odds ratio of 0.444.

Mendelian randomizationMechanisms

Paper

Scientific ReportsJan 18

Integrative analysis of plasma small-molecule and gut-microbiome markers of sarcopenia in a pilot study within an Indian cohort

Cohort study of 40 peopleSarcopenia

Paper

Lipids in Health and DiseaseApr 5

Age and sex are associated with the plasma lipidome: findings from the GOLDN study

Cross-sectional study of 980 peopleMechanisms

Paper

MedicineSep 28

Unveiling the association between plasma lipid species and pan-cancers: A bidirectional 2-sample Mendelian randomization study

Mendelian randomization in peopleMechanisms

Paper

MedicineSep 15

Plasma lipid species, immune cell traits, and gastric cancer risk: A Mendelian randomization study

Mendelian randomization in peopleBlood and immune system

Paper

GeroScienceJul 2

Blood fats linked to heart aging in American Indians

Researchers measured 1,542 blood fats twice in 1,801 American Indians, linking several to heart-aging measures and some to later coronary heart disease.Researchers measured 1,542 blood fats twice in 1,801 American Indians, linking several to heart-aging measures and some to later coronary heart disease.

Cohort · 1,801 peopleBiomarkers