Plaque index

1 paper1 finding

Human trial1

Interventions

1

Metformin

downin humans1

1 study

Metformin decreases plaque index in humans (0.49 vs. 1.37).
“At 6 months, the test group showed significantly lower PI (0.49 vs. 1.37, P < 0.001)”
Human trialPeri-implantitis; adjunctive to mechanical debridement versus mechanical debridement alonegel1%6 monthsn = 54
Harnessing the Therapeutic Potential of Locally Delivered 1% Metformin Gel for Modulation of Clinical and Inflammatory Parameters in Peri-Implantitis Disease: A Prospective Clinical Evaluation
Journal of long-term effects of medical implants1 Jan 2026

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