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Phospho-STAT3

There are 7 papers on phospho-STAT3 in aging research: 2 observational studies in people, 4 in animals, 1 in cells.

Biomarker

7 papers study it1 more mentions it2 findings

See all 8 papers on phospho-STAT3

“lower expression of pSTAT3 (OR 0.35, 95% CI 0.13-0.82, p = 0.01) and higher expression of plasminogen”
Postlactational involution biomarkers plasminogen and phospho-STAT3 are linked with active age-related lobular involutionBreast cancer research and treatment2017doi:10.1007/s10549-017-4413-3
  • Humans2
  • Animals4
  • Cells1

Interventions

1

Anti-amyloid beta antibody

upin mice1

1 study

  1. Anti-amyloid beta antibody increases phospho-STAT3 in mice (Tg2576 mice).

    “passive immunization with anti-Abeta antibody conversely restored hippocampal p-STAT3 levels in Tg2576 mice”

    AnimalsTg2576 micehippocampus

    Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

    Molecular psychiatry

More on Anti-amyloid beta antibody

Associations

1

Progressive age-related lobular involution

upin humans1OR 0.35

1 study

  1. Phospho-STAT3 is associated with progressive age-related lobular involution in humans (Lower expression; models simultaneously adjusted for all biomarkers) (OR 0.35, 95% CI 0.13-0.82, p = 0.01).

    “lower expression of pSTAT3 (OR 0.35, 95% CI 0.13-0.82, p = 0.01) and higher expression of plasminogen”

    HumansLower expression; models simultaneously adjusted for all biomarkersbreastfemalesn = 57

    Postlactational involution biomarkers plasminogen and phospho-STAT3 are linked with active age-related lobular involution

    Breast cancer research and treatment

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