PGP9.5+ nerve fiber length

Older age is associated with PGP9.5+ nerve fiber length in mice (approximately 2.0-fold greater than young males).

“aged males showed approximately 2.0-fold greater total PGP9.5+ nerve fiber length and 3.6-fold higher PGP9.5+ branching complexity compared with young males.”

Animalsanterior knee jointmales

3D Light sheet microscopy reveals aging osteoarthritis-associated joint-innervated nerve remodeling in mouse knee joints

Osteoarthritis and cartilage·23 Apr 2026