Percentage of critically short telomeres

1. Circadian clock is associated with percentage of critically short telomeres in humans.

   “Greater regularity in sleep/wake patterns was associated with a decrease in 50th and 20th percentile TL and an increase in %CST”

   Humansgreater regularity in sleep/wake patternsblood18-month follow-upn = 124

   Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk · AAIC 2025 abstract · 7 Jan 2026

Circadian clock →

1. Sleep predicts percentage of critically short telomeres in humans.

   “Poor sleep quality (lower sleep efficiency and higher WASO) and greater variability in sleep efficiency predicted an increase in %CST”

   Humanspoor sleep quality (lower sleep efficiency and higher WASO) and greater variability in sleep efficiencyblood18-month follow-upn = 124

   Telomere Dynamics Influenced by Sleep, Sleep Variability and Circadian Rhythms in Older Adults With and Without Alzheimer's Risk · AAIC 2025 abstract · 7 Jan 2026