PC2 SASP signature

1. PC2 SASP signature predicts primary sclerosing cholangitis in humans (AUC = 0.83).

   “control vs. early-stage PSC (AUC = 0.83).”

   Humansearly-stage PSC vs. controls

   Plasma Biomarkers of Senescence in Cholestatic Liver Disease: A Signature of Risk Stratification and Progression

   Journal of gastroenterology and hepatology·13 Feb 2026

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