Passenger mutation burden

1. Passenger mutation burden is associated with mortality in humans.

   “passenger burden strongly associated with incident hematologic malignancy and mortality”

   Humansbloodn = 791,067

   Multi-ancestry analysis of 791K whole genomes reveals the genetic, geographic, and phenotypic correlates of somatic passenger mutations in blood

   medRxiv·25 Aug 2026Preprint

1. Passenger mutation burden is associated with incident hematologic malignancy in humans.

   “passenger burden strongly associated with incident hematologic malignancy and mortality”

   Humansbloodn = 791,067

   Multi-ancestry analysis of 791K whole genomes reveals the genetic, geographic, and phenotypic correlates of somatic passenger mutations in blood

   medRxiv·25 Aug 2026Preprint

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