PAA

1. PAA has no effect on mental health in humans.

   “Neither PAA nor change in PAA was associated with MCS in either population.”

   Humanscancer survivors and individuals without cancer

   Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer

   Journal of cancer survivorship : research and practice·30 Apr 2025

1. PAA increases depression in humans (0.57, 95% CI 0.27, 0.88).

   “and with higher depression scores among those without a cancer history (0.57, 95% CI 0.27, 0.88).”

   Humanswithout a cancer history

   Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer

   Journal of cancer survivorship : research and practice·30 Apr 2025

More on Depression

1. PAA impairs physical function in humans (-1.73, 95% CI -3.11, -0.35 per 5 years).

   “PAA was associated with lower PCS (adjusted coefficients per additional 5 years; cancer survivors, - 1.73, 95% CI - 3.11, - 0.35”

   Humanscancer survivorsper additional 5 years

   Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer

   Journal of cancer survivorship : research and practice·30 Apr 2025

1. PAA raises the risk of dementia in humans (HR: 1.20, 95% CI: 1.04, 1.36).

   “Midlife PAA is associated with higher dementia risk (hazard ratio[HR]: 1.20 [CI: 1.04, 1.36])”

   Humans

   Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

   Communications medicine·14 Aug 2025

More on Dementia

1. PAA is associated with global cognition in humans (difference: -0.11, 95% CI: -0.16, -0.06).

   “In ARIC, every five years, PAA is associated with lower global cognition: difference: -0.11, 95% confidence interval[CI]: -0.16, -0.06) using midlife PAA”

   Humansevery five years PAA

   Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

   Communications medicine·14 Aug 2025