p16Ink4a+ fibroblasts
1 paper2 findings
- Animals1
Interventions
1XL888
downin human cells1downin mice1
1 study
XL888
downin human cells1downin mice1
XL888 decreases p16Ink4a+ fibroblasts in human cells.
“reduced p16INK4a+ fibroblasts from IPF PCLS ex vivo.”
Cellsfrom patients with idiopathic pulmonary fibrosislung
The Journal of clinical investigation7 Mar 2024
XL888 decreases p16Ink4a+ fibroblasts in mice.
“XL888 treatment eliminated pathogenic p16Ink4a+ fibroblasts in a murine model of lung fibrosis”
Animalsin a murine model of lung fibrosislung
The Journal of clinical investigation7 Mar 2024
Funding
3 grants since 2022National Heart, Lung, and Blood InstituteUS$2.5m
p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP
National Heart, Lung, and Blood InstituteUniversity of California, San DiegoUS$249k2024–2027
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosis
National Heart, Lung, and Blood InstituteUniversity of California, San FranciscoUS$556.9k2022–2025
p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP
National Heart, Lung, and Blood InstituteUniversity of California, San FranciscoUS$178k2023–2024