What does the research say about p-tau181/Abeta1-42 ratio?

p-tau181/Abeta1-42 ratio

There are 2 papers on p-tau181/Abeta1-42 ratio in aging research: 1 trial and 1 observational study in people.

2 papers study it1 finding

“Levels of p-tau181, Aβ1-42, and p-tau181/Aβ1−42 ratio were significantly associated with spatial cognition scores on both tasks.”

Spatial cognition

downin humans1

1 study

p-tau181/Abeta1-42 ratio is associated with spatial cognition in humans (β = -0.04/0.05, p < 0.001).
“Levels of p-tau181, Aβ1-42, and p-tau181/Aβ1−42 ratio were significantly associated with spatial cognition scores on both tasks.”
Humanscerebrospinal fluidn = 1,875
Spatial cognition is associated with levels of phosphorylated-tau and β-amyloid in clinically normal older adults
Neurobiology of agingJun 29, 2023