There are 8 papers on nuclear Nrf2 levels in aging research: 1 trial in people, 8 in animals. The newest story, Nov 9, 2026: “Gene variants shape antioxidant defenses in aging mouse brains”.
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1 new paper in 30 daysSee all 10 papers on nuclear Nrf2 levels
Pentoxifylline
upin rats1
Pentoxifylline increases nuclear Nrf2 levels in aged rats.
“increased the GSH/GSSG ratio, mitochondrial ATP, nuclear Nrf2, and cAMP levels, and upregulated PGC-1α”
Animalsin aged ratsbrain
Aging
Resveratrol
upin mice1
Resveratrol increases nuclear Nrf2 levels in mice (SAMP8 Alzheimer's disease mouse model).
“the nuclear Nrf2 content and the nuclear translation rate of Nrf2 were increased (P<0.05).”
AnimalsSAMP8 Alzheimer's disease mouse modelbrain20 or 40 mg/kg15 days
Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer's Disease
BioMed research international
Accelerated aging phenotype
downin mice1
Accelerated aging phenotype decreases nuclear Nrf2 levels in SAMP8 vs SAMR1 mice.
“The protein level of Nrf2 in the nucleus of the liver was significantly decreased in SAMP8 at 10 months old compared with that in age-matched SAMR1.”
Animalsin SAMP8 vs SAMR1 miceliver
Age-related changes of Nrf2 and phosphorylated GSK-3β in a mouse model of accelerated aging (SAMP8)
Archives of gerontology and geriatrics
Experiments in mice carrying human ApoE4 found lower antioxidant protein levels in youth and accumulating products of fat oxidation with age.Experiments in mice carrying human ApoE4 found lower antioxidant protein levels in youth and accumulating products of fat oxidation with age.