Nuclear mitochondrial DNA insertions

1. SURF1 increases nuclear mitochondrial DNA insertions in human cells (4.7-fold).

   “patient-derived SURF1-mutant cells exhibiting mtDNA instability accumulated Numts 4.7-fold faster than healthy donors.”

   CellsSURF1-mutant cells

   Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

   PLoS biology·Aug 22, 2024

More on SURF1

1. Dorsolateral prefrontal cortex increases nuclear mitochondrial DNA insertions in humans (5.5-fold).

   “Within brain samples, we observed a 5.5-fold enrichment of somatic Numt insertions in the dorsolateral prefrontal cortex (DLPFC) compared to cerebellum samples”

   Humansdorsolateral prefrontal cortex

   Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

   PLoS biology·Aug 22, 2024

1. Nuclear mitochondrial DNA insertions are associated with earlier mortality in humans (~2 more Numts per decade of life lost).

   “The brains of individuals with no cognitive impairment (NCI) who died at younger ages carried approximately 2 more Numts per decade of life lost than those who lived longer.”

   Humansbrain

   Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

   PLoS biology·Aug 22, 2024