Neurofibrillary tangle burden

Neurofibrillary tangle burden is associated with end-of-life body mass index in humans (Negative correlation).

“We also identified a negative correlation between the burden of entorhinal cortical neurofibrillary tangles and end-of-life body mass index in PWH.”

HumansVirally suppressed people with HIVentorhinal cortexn = 13

Neuropathologic findings in a community-based autopsy cohort of older, virally suppressed, people with HIV

Journal of neuropathology and experimental neurology·Aug 29, 2025

Superaging is associated with neurofibrillary tangle burden in humans.

“SuperAgers had significantly fewer stereologically quantified Alzheimer's disease-related neurofibrillary tangles in layer II ERC than Normal Elderly (p < 0.05)”

Humansentorhinal cortex layer II

Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging

The Journal of neuroscience : the official journal of the Society for Neuroscience·Sep 30, 2022