Netrin-1 and NGF secretion

Senescent osteoclast increases Netrin-1 and NGF secretion in mice.

“there is significantly increased SnOC-mediated secretion of Netrin-1 and NGF, two well-established sensory nerve growth factors, compared to non-senescent OCs.”

Animalscompared with non-senescent osteoclastsosteoclast

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

eLife·10 Apr 2024Preprint