Myonuclear content

Myonuclear content is associated with muscle fiber cross-sectional area in humans.

“Myonuclear content of MyHC II fibers was ~30% higher in young compared with old and was closely associated with CSA in both fiber types.”

Humansvastus lateralis

Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle

bioRxiv : the preprint server for biology·13 Feb 2026Preprint