EMBO Reports
Amyloid linked to reduced mitochondrial cleanup in neurons
Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing…Experiments in neuronal cells linked amyloid precursor protein and one amyloid fragment to reduced removal of damaged mitochondria, the cells’ energy-producing structures.
Human cell studyInterventions
Who was studiedDifferentiated human SH-SY5Y neurons, against MUT-APP-transfected cells
What changedNeurons expressing wild-type APP showed lower mitophagy proximity signals than neurons expressing mutant APP
The catchMitophagy was scored by proximity and dye assays; degradation flux was not measured