mtDNA A H >G H substitution frequency

mtDNA A H >G H substitution frequency is associated with cellular and organismal longevity in silico.

“we observed that the frequency of A H >G H substitutions ( H - heavy chain notation) is positively correlated with cellular and organismal longevity.”

In silico

Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging

bioRxiv (Cold Spring Harbor Laboratory)·Mar 26, 2019Preprint