Microglial population composition

Age is associated with microglial population composition in humans.

“Between the ages of 50 to 75, embryonic yolk sac-derived microglia were depleted and replaced by cells resembling peripheral blood monocyte-derived microglia.”

Humanshippocampus

Epigenetic and 3D genome reprogramming during the aging of the human hippocampus

Science (New York, N.Y.)·23 Jul 2026