Microbiome features

1. Microbiome features showed no clear effect on lifespan in flies.

   “microbiome features of young flies including diversity indices, taxonomic abundances, or ordination scores cannot predict age-associated phenotypes (lifespan, locomotor activity, dry weight, and heat knockdown time).”

   Model organisms

   Young flies’ microbes did not predict lifespan or aging traits

   Biogerontology·May 4, 2026

2. Microbiome features showed no clear effect on lifespan in mice.

   “the microbiome is significantly associated with multiple health parameters — including body composition, immune parameters, and frailty — but not with lifespan.”

   Animalsintestinen = 913

   Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice

   bioRxiv (Cold Spring Harbor Laboratory)·Nov 29, 2023Preprint

1. Microbiome features showed no clear effect on locomotor activity in flies.

   “microbiome features of young flies including diversity indices, taxonomic abundances, or ordination scores cannot predict age-associated phenotypes (lifespan, locomotor activity, dry weight, and heat knockdown time).”

   Model organisms

   Young flies’ microbes did not predict lifespan or aging traits

   Biogerontology·May 4, 2026

1. host genetics are associated with microbiome features in mice.

   “the majority of taxonomic and functional microbiome features show small but significant heritability”

   Animalsintestine

   Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice

   Nature microbiology·Mar 31, 2025

2. host genetics are associated with microbiome features in mice (variation explained by host genetics as large as that of aging and dietary restriction).

   “the majority of microbiome features are significantly heritable”

   Animalsintestinen = 913

   Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice

   bioRxiv (Cold Spring Harbor Laboratory)·Nov 29, 2023Preprint

1. Smoking cessation is associated with microbiome features in humans.

   “revealed a profound effect of smoking cessation on epigenetic biomarkers and microbiome features across multiple organ systems within 6 months of smoking cessation”

   Human trial6 months

   Longitudinal multi-omic evaluation of biomarkers of health and ageing over smoking cessation intervention

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 4, 2025Preprint

More on Smoking cessation

1. Microbiome features are associated with health parameters in mice.

   “the microbiome is significantly associated with multiple health parameters”

   Animalsintestinen = 913

   Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice

   bioRxiv (Cold Spring Harbor Laboratory)·Nov 29, 2023Preprint