Metabolic and inflammatory markers

1. Empagliflozin + topiramate showed no clear effect on metabolic and inflammatory markers in humans (at week 12, versus placebo, with calorie-restricted diet) (P > 0.05).

   “At week 12, no statistically significant difference was observed between the two groups in any of mentioned variables (P > 0.05).”

   Human trialat week 12, versus placebo, with calorie-restricted dietempagliflozin 10 mg daily; topiramate 25 mg once daily then twice daily12 weeksn = 44

   Randomized study of the effects of empagliflozin and topiramate dual therapy on anthropometric and metabolic indices in non-diabetic individuals with overweight/obesity on a calorie-restricted diet

   Eating and weight disorders : EWD·Oct 3, 2024

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1. Advanced Horvath DNA methylation age was not clearly linked with metabolic and inflammatory markers in humans.

   “No associations emerged between advanced Horvath DNAm age and any of the examined biological parameters.”

   Humanstwo yearsn = 179

   Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome

   Aging·Jun 7, 2019

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1. exomiR clusters are associated with metabolic and inflammatory markers in humans.

   “MiRs formed two hierarchical clusters being indicative of positive or negative health outcomes involving associations with body composition, serum 17β-estradiol, fat-, glucose- and inflammatory markers.”

   Humansfemales

   Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy

   Scientific reports·Feb 14, 2017

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