MCM2-7 expression

1 paper1 finding

Cells1

Upstream

1

TP53

downin mouse cells1

1 study

TP53 decreases MCM2-7 expression in mouse cells.
“The MCM2-7 reduction in response to RS is TRP53-dependent”
Cellsin response to replication stress
Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation
PLoS genetics14 Jan 2016

Latest

PLOS Genetics14 Jan

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

Experiments in mouse cellsMechanisms