Macular retinal nerve fiber layer thickness

1. APOE decreases macular retinal nerve fiber layer thickness in humans (β = −0.14 [95% CI, −0.23 to −0.05]; p = .002).

   “APOE ε4 genotype was significantly associated with baseline mRNFL thickness, showing a stepwise decline across ε4 non‐carriers, heterozygotes, and homozygotes (β = −0.14 [95% CI, −0.23 to −0.05]; p = .002).”

   Humans12.49 yearsn = 35,433

   Thinning of the Retinal Nerve Fiber Layer and Incident Dementia Over 12 Years: A Prospective Cohort Study of 35 433 Participants

   AAIC 2025 abstract·24 Dec 2025

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