Frontiers in Immunology
Blocking an immune signal sped wound closure in aged mice
Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.Blocking CCL3, a signal that attracts immune cells, from day four after injury reduced their accumulation and accelerated wound closure in aged mice.
Mouse studyImmune response
Who was studiedAged mice with skin wounds, 7 dpw, against aged mice receiving control antibody
What changedBlocking CCL3 reduced wound area in aged mice compared with control antibody
The catchExcluding wounds with hair-cycle changes could bias the wound-closure comparison