Lysosomal metabolite changes

1. Caloric restriction decreases lysosomal metabolite changes.

   “Caloric restriction, a lifespan-extending intervention, mitigated these changes in the heart and muscle but not the brain.”

   Animalsheart

   Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

   Science (New York, N.Y.)·30 Jul 2026

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