Low CD4/CD8 ratio

1. Low CD4/CD8 ratio is associated with senescent CD8+ T-cell abundance in humans (Adjusted OR 0.93, 95% CI 0.88–0.97; p = 0.003).

   “those with a CD4/CD8 ratio < 0.76 had more senescent CD8+ cells (AdjOR = 0.93, 95%CI = [0.88; 0.97], p-value = 0.003).”

   HumansPLWH on successful stable ART; CD4/CD8 ratio < 0.76; adjusted for age, gender, HIV follow-up and ART durationCD8+ T-celln = 68

   Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV

   Frontiers in medicine·15 Apr 2025

More on Senescent CD8+ T-cell abundance

1. Low CD4/CD8 ratio is associated with T-cell IFNγ/IL-2 secretion in humans.

   “and enhanced T-cell IFNγ/IL-2 secretion.”

   HumansVirally suppressed HIV infection with CD4≥500T-cellThree years of ART

   The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

   Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·22 Aug 2024

More on T-cell IFNγ/IL-2 secretion

1. Low CD4/CD8 ratio is associated with CD8 T-cell senescent phenotype in humans.

   “R < 0.8 at follow-up showed most alterations in CD8 subsets (increasing frequency and exhibiting a senescent phenotype [e.g., CD57+, CD95+])”

   HumansVirally suppressed HIV infection with CD4≥500CD8 T-cellThree years of ART

   The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

   Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·22 Aug 2024

1. Low CD4/CD8 ratio is associated with baseline thymic function in humans.

   “R < 0.8 presented lower baseline thymic function, being inversely correlated with post-ART inflammation.”

   HumansVirally suppressed HIV infection, CD4≥500; CD4/CD8 ratio <0.8 versus >1.2thymusThree years of ART

   The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

   Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·22 Aug 2024

1. Low CD4/CD8 ratio is associated with pre-ART inflammatory markers in humans.

   “R < 0.8 showed a differential inflammatory profile compared to R > 1.2 (increased β2-microglobulin, D-dimers and IP-10 before ART).”

   HumansVirally suppressed HIV infection, CD4≥500; CD4/CD8 ratio <0.8 versus >1.2Three years of ART

   The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

   Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·22 Aug 2024

More on pre-ART inflammatory markers