Senescent CD8+ T-cell abundance

1. Low CD4/CD8 ratio is associated with senescent CD8+ T-cell abundance in humans (Adjusted OR 0.93, 95% CI 0.88–0.97; p = 0.003).

   “those with a CD4/CD8 ratio < 0.76 had more senescent CD8+ cells (AdjOR = 0.93, 95%CI = [0.88; 0.97], p-value = 0.003).”

   HumansPLWH on successful stable ART; CD4/CD8 ratio < 0.76; adjusted for age, gender, HIV follow-up and ART durationCD8+ T-celln = 68

   Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV

   Frontiers in medicine·15 Apr 2025

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