Locus coeruleus contrast-to-noise ratio

1. Locus coeruleus contrast-to-noise ratio is associated with cortical tau SUVr in humans.

   “Associations between LC integrity and cortical tau were restricted to temporal lobes, including parahippocampal gyrus, and inferior parietal regions”

   Humansasymptomatic, at-risk older adults with first-degree familial history of Alzheimer's diseasetemporal lobes and inferior parietal regionsn = 208

   Locus coeruleus structural integrity relates to cortical amyloid and tau pathology in vivo

   AAIC 2025 abstract·23 Dec 2025

More on Cortical tau SUVr

1. Locus coeruleus contrast-to-noise ratio is associated with cortical amyloid SUVR in humans.

   “We observed negative associations between LC integrity and amyloid SUVR across almost all cortical regions”

   Humansasymptomatic, at-risk older adults with first-degree familial history of Alzheimer's diseasebrainn = 208

   Locus coeruleus structural integrity relates to cortical amyloid and tau pathology in vivo

   AAIC 2025 abstract·23 Dec 2025

More on Cortical amyloid SUVR