LDL-C burden

1. LDL-C burden raises the risk of myocardial infarction in humans (HR 1.66, 1.52-1.82).

   “The association was stronger for MI (HR 1.66, 1.52-1.82) than for stroke (HR 1.32, 1.20-1.46).”

   HumansType 2 diabetes, 4 vs. 0 LDL-C elevation episodes

   Layered Effects of LDL-C Burden and Variability on Cardiovascular Events and Mortality in Type 2 Diabetes: A Nationwide Cohort Study

   Diabetes, obesity & metabolism·17 Sep 2026

More on Myocardial infarction

1. LDL-C burden raises the risk of cardiovascular disease in humans (HR 1.49 (1.39-1.60)).

   “adjusted HRs increased from 1.10 (95% CI 1.04-1.15) to 1.49 (1.39-1.60).”

   HumansType 2 diabetes, 4 vs. 0 LDL-C elevation episodes

   Layered Effects of LDL-C Burden and Variability on Cardiovascular Events and Mortality in Type 2 Diabetes: A Nationwide Cohort Study

   Diabetes, obesity & metabolism·17 Sep 2026

More on Cardiovascular disease

1. LDL-C burden is associated with coronary heart disease in humans (p < 0.01).

   “Subjects with CHD had higher LDL-C burden at all ages tested (45, 50 and 60 years) compared with the non-CHD group (p < 0.01, also after adjusting for sex)”

   Humansin elderly familial hypercholesterolemia patients

   LDL cholesterol burden in elderly patients with familial hypercholesterolemia: Insights from real-world data

   American journal of preventive cardiology·29 Mar 2025

More on Coronary heart disease