lacZ mutation frequency

1. High temperature increases lacZ mutation frequency in flies.

   “they do so much more quickly at higher temperature”

   Model organismsaging flies

   Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster

   PLoS genetics·13 May 2010

More on High temperature

1. SOD1 has no effect on lacZ mutation frequency in mice.

   “No increased mutation accumulation was observed in brain or spleen.”

   AnimalsSod1 deficiencybrain and spleen

   Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice

   Cancer research·15 Dec 2005

2. SOD1 increases lacZ mutation frequency in mice (twice as high).

   “At 2 months of age, the lacZ mutation frequency in the liver of the hybrid animals was already twice as high as in littermate controls of the same age.”

   AnimalsSod1 deficiencyliver

   Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice

   Cancer research·15 Dec 2005

More on SOD1

1. Drosophila melanogaster increases lacZ mutation frequency in flies (three times as high).

   “mutation frequency at the lacZ locus in somatic tissue of flies is about three times as high as in mouse tissues”

   Model organismssomatic tissue

   Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster

   PLoS genetics·13 May 2010

More on Drosophila melanogaster

1. Age is associated with lacZ mutation frequency in flies.

   “somatic mutations in the fly also accumulate as a function of age”

   Model organismssomatic tissue

   Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster

   PLoS genetics·13 May 2010