Joint space narrowing

1. Glucosamine decreases joint space narrowing in humans (P=0.10; narrowing of 6.0% vs 14.9%).

   “In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing.”

   Human trialin patients with mild OA (highest quartile of baseline mean JSW)knee3 years

   Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate

   Osteoarthritis and cartilage·Jan 1, 2003

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1. Osteoarthritis is associated with joint space narrowing in humans (RR of 0.42 (0.17-1.01)).

   “Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint.”

   Human trialcompared to those with less affected jointknee3 years

   Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate

   Osteoarthritis and cartilage·Jan 1, 2003

More on Osteoarthritis

1. Joint space width is associated with joint space narrowing in humans (r=-0.34, P=0.003).

   “In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003).”

   Human trialin placebo groupknee3 years

   Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate

   Osteoarthritis and cartilage·Jan 1, 2003

More on Joint space width