Immune response gene expression

1. Fukomys damarensis increases immune response gene expression in F. damarensis after carcinogen exposure.

   “DMRs upregulated genes associated with both T cell-mediated and innate immune responses, reflecting broad immune activation”

   Animalsafter carcinogen exposure

   Two mole-rat species resist skin cancer but differ in immune response

   GeroScience·Oct 26, 2026

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1. Achl inhibits immune response gene expression in flies (shown by Achilles knockdown).

   “Achilles knock-down in neurons dramatically elevates expression of crucial immune response genes, including IM1 (Immune induced molecule 1), Mtk (Metchnikowin), and Drs (Drosomysin).”

   Model organismsshown by Achilles knockdownneuron

   Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila

   Brain, behavior, and immunity·Nov 14, 2016

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1. gut bacterial imbalance is associated with immune response gene expression in mice.

   “and negatively with the expression of tight junction genes (Jam2, Tjp1, and Tjp2), as well as immune response genes (Cd4, Cd72, Tlr7, Tlr12, and Lbp).”

   Animalscolonfemales

   Intestinal Permeability, Gut Inflammation, and Gut Immune System Response Are Linked to Aging-Related Changes in Gut Microbiota Composition: A Study in Female Mice

   The journals of gerontology. Series A, Biological sciences and medical sciences·Feb 17, 2024