There is 1 paper on Achl in aging research: none in people yet, 1 in animals.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 1 more
- Model organisms1
Effects
3Locomotor activity
no changein flies1
1 study
Locomotor activity
no changein flies1
Achl showed no clear effect on locomotor activity in flies (shown by Achilles knockdown).
“Meanwhile, no significant change in core clock gene expression and locomotor activity is observed”
Model organismsshown by Achilles knockdown
Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila
Brain, behavior, and immunity
Core clock gene expression
no changein flies1
1 study
Core clock gene expression
no changein flies1
Achl showed no clear effect on core clock gene expression in flies (shown by Achilles knockdown).
“Meanwhile, no significant change in core clock gene expression and locomotor activity is observed”
Model organismsshown by Achilles knockdown
Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila
Brain, behavior, and immunity
Immune response gene expression
downin flies1
1 study
Immune response gene expression
downin flies1
Achl inhibits immune response gene expression in flies (shown by Achilles knockdown).
“Achilles knock-down in neurons dramatically elevates expression of crucial immune response genes, including IM1 (Immune induced molecule 1), Mtk (Metchnikowin), and Drs (Drosomysin).”
Model organismsshown by Achilles knockdownneuron
Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila
Brain, behavior, and immunity