Imidazole propionate

2 papers2 findings

Humans2

Interventions

1

Dietary fiber

downin humans1

1 study

Dietary fiber decreases imidazole propionate in humans.
“Higher fiber intake was associated with lower serum ImP and ImP-to-histidine ratio”
Humansserum
Diet, Gut Microbiota, and Histidine Metabolism toward Imidazole Propionate Production in Relation to Type 2 Diabetes
ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Dietary fiber

Associations

1

Type 2 diabetes

upin humans1HR 1.17

1 study

Imidazole propionate raises the risk of type 2 diabetes in humans (HR 1.17 [95% CI: 1.00-1.36]).
“Serum ImP and ImP-to-histidine ratio were positively associated with incident T2D (Hazard ratio=1.17 [95% CI:1.00-1.36] and 1.33 [1.14-1.55], respectively, comparing highest to lowest tertile)”
Humansserum~12 yearsn = 4,632
Diet, Gut Microbiota, and Histidine Metabolism toward Imidazole Propionate Production in Relation to Type 2 Diabetes
ADA Scientific Sessions 2025 abstract13 Jun 2025

More on Type 2 diabetes

Funding

1 grant since 2024

National Institute on AgingUS$407.6k

Exploring the role of Imidazole Propionate on Alzheimer’s Disease and Related Dementias
National Institute on AgingUniversity of Wisconsin-madisonUS$184.4k2024–2027

Latest

1 in 12 months

AAIC 2025 Abstract9 Jan

Plasma Levels of the Gut Bacteria‐Derived Metabolite Imidazole Propionate Are Negatively Associated with Cognitive Scores

Cohort study of 1,118 peoplePopulations

ADA Scientific Sessions 2025 Abstract13 Jun

Diet, Gut Microbiota, and Histidine Metabolism toward Imidazole Propionate Production in Relation to Type 2 Diabetes

Cohort study of 4,632 peopleType 2 diabetes