Il1b and Ccl2 expression
1 paper studies it2 findings
- Animals1
Interventions
2Elamipretide + nicotinamide mononucleotide
downin mice1
1 study
Elamipretide + nicotinamide mononucleotide
downin mice1
Elamipretide + nicotinamide mononucleotide decreases Il1b and Ccl2 expression in mice.
“ELAM+NMN-treated aged mice accumulated uremic toxins like NMN-only aged mice, but reduced IL-1-beta; and Ccl2 kidney mRNA.”
Animalsaged micekidneyelamipretide 3 mg/kg/day + NMN 300 mg/kg/day8 weeksmales
Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation
bioRxiv : the preprint server for biologyPreprint
Nicotinamide mononucleotide
upin mice1
1 study
Nicotinamide mononucleotide
upin mice1
Nicotinamide mononucleotide increases Il1b and Ccl2 expression in mice.
“Unexpectedly, in aged kidneys, NMN increased expression of genetic markers of inflammation (IL-1-beta; and Ccl2) and tubule injury (Kim-1).”
Animalsaged micekidney300 mg/kg/day8 weeksmales
Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation
bioRxiv : the preprint server for biologyPreprint
Latest
bioRxiv
Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation
Preprint: experiments in miceNicotinamide mononucleotide