IFN-γ-producing CD4+ T cells

1. anti-CMV IgG is associated with IFN-γ-producing CD4+ T cells in humans.

   “CMV-related immune remodeling-including higher anti-CMV IgG levels and expansions of differentiated CD8+ subsets-correlated with diminished IFN-γ responses in CD4+ and CD8+ T cells after boosting”

   Human trialn = 41

   Immunosenescence and cytomegalovirus-associated immune signatures on severe acute respiratory syndrome coronavirus 2 booster responses

   The journals of gerontology. Series A, Biological sciences and medical sciences·7 Apr 2026

More on anti-CMV IgG

1. Older-adults are associated with IFN-γ-producing CD4+ T cells in humans.

   “older adults and males exhibited significantly lower post-boost frequencies of IFN-γ-producing CD4+ T cells”

   Human trialmalesn = 41

   Immunosenescence and cytomegalovirus-associated immune signatures on severe acute respiratory syndrome coronavirus 2 booster responses

   The journals of gerontology. Series A, Biological sciences and medical sciences·7 Apr 2026