Hypervascular proteomic signature

1. Hypervascular proteomic signature is associated with vascular dementia in humans.

   “showed strong alignment between the mouse hypervascular signature and vascular dementia risk, but minimal concordance with Alzheimer’s disease”

   Humanscross-species comparison with UK Biobank human proteomic biomarkers

   Reversible hypervascularization drives cognitive decline and blood-brain barrier damage during aging

   bioRxiv (Cold Spring Harbor Laboratory)·6 May 2026Preprint

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