Horvath multi-tissue clock

heterochromatin increases Horvath multi-tissue clock in silico (1.94-fold).

“Zone 3 is enriched 1.94-fold (P = 2.0 × 10−5) for the CpG sites composing Horvath's multi-tissue epigenetic aging clock”

In silicoCpG sites gaining methylation with age

A single formula predicts where cancer mutations and epigenetic aging converge from DNA sequence alone

Zenodo (CERN European Organization for Nuclear Research)·20 Mar 2026Preprint

Chronological age is associated with Horvath multi-tissue clock in humans (r = 0.65, p < 0.001).

“Horvath clock, r = 0.65, p < 0.001 for MEN1-relatd NEN”

Humansin MEN1-related NEN

Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms

Clinical epigenetics·9 Feb 2026