Homeostatic dysregulation score

1. Homeostatic dysregulation score raises the risk of colorectal cancer in humans (HR 1.35, 95% CI 1.08-1.69).

   “and 1.35 [1.08-1.69] for HD score) than late-onset CRC (HR [95% CI]: 1.06 [1.03-1.09] for PhenoAge acceleration and 1.05 [1.02-1.08] for HD score)”

   Humansearly-onset CRC

   Accelerated biological aging and its hallmarks in DNA methylation drive the association between unhealthy lifestyles and the onset of colorectal cancer

   EBioMedicine·5 Nov 2025

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