Heteroplasmic mtDNA mutations

1. Heteroplasmic mtDNA mutations raise the risk of acute kidney injury in humans (P < 10−7).

   “an independent increase in the risk of future acute kidney injury events (P < 10−7)”

   Humansn = 369,912

   Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

   Science (New York, N.Y.)·4 Sep 2025

More on Acute kidney injury

1. Heteroplasmic mtDNA mutations are associated with chronic kidney disease severity in humans.

   “graded association between mutation burden and chronic kidney disease severity”

   Humansn = 369,912

   Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

   Science (New York, N.Y.)·4 Sep 2025