H4K16 acetylation

1 paper studies it5 more mention it1 finding

Humans1

Upstream

1

LMNA

downin human cells1

1 study

LMNA decreases H4K16 acetylation in human cells.
“Proteomic analyses identified abnormal acetylation programs in HGPS VSMC replication fork complexes, resulting in reduced H4K16 acetylation.”
Cellsin HGPS VSMCsvascular smooth muscle cells
Progeria-based vascular model identifies networks associated with cardiovascular aging and disease
Aging cellApr 4, 2024

Latest

1 paper in 12 months

AgingMar 6

P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts

Experiments in human cellsp38 MAPK signaling

Aging CellApr 5

Progeria-based vascular model identifies networks associated with cardiovascular aging and disease

Study in peopleLMNA

BiogerontologyJul 20

Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells

Experiments in human cellsMechanisms

Nature MetabolismJun 30

The SESAME complex regulates cell senescence through the generation of acetyl-CoA

Experiments in cellsMechanisms

EMBO ReportsAug 11

The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors

Experiments in model organismsMechanisms

PNASFeb 14

Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice

Experiments in miceMechanisms