Grey-white matter contrast

1. Alzheimer's disease decreases grey-white matter contrast in humans.

   “Symptomatic mutation carriers had lower GWC than non‐carriers in ROIs: the precuneus and superior parietal lobe ( p < 0.05)”

   Humanssymptomatic mutation carriers vs non-carriersbrain

   Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

   AAIC 2025 abstract·7 Jan 2026

More on Alzheimer's disease

1. Grey-white matter contrast is associated with proximity to symptom onset in humans.

   “Lower GWC was associated with closer proximity to symptom onset in both the inferior parietal and supramarginal cortices”

   Humanspresymptomatic mutation carriersbrain

   Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

   AAIC 2025 abstract·7 Jan 2026

1. Grey-white matter contrast is associated with estimated years to onset in humans.

   “In presymptomatic mutation carriers, GWC was significantly correlated with EYO (a proxy measure of disease stage).”

   Humanspresymptomatic mutation carriersbrain

   Grey‐White matter contrast as an early brain pathology marker in Familial Alzheimer's disease

   AAIC 2025 abstract·7 Jan 2026

More on Estimated years to onset