Global and Tfam-specific DNA methylation

1. Mitochondrial transplantation decreases global and Tfam-specific DNA methylation in rats.

   “significant (p < 0.05) epigenetic changes (i.e., hypomethylation) at the global and site-specific levels for a key mitochondrial regulator (transcription factor A mitochondrial)”

   Animalslow-capacity running rats; compared with placeboisolated mitochondriahindlimb muscle4 weeksmales

   Mitochondria Transplantation: Rescuing Innate Muscle Bioenergetic Impairment in a Model of Aging and Exercise Intolerance

   Journal of strength and conditioning research·20 Jun 2024

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