Genetic susceptibility to complex diseases

Biomarker

1 paper2 findings

  • Humans1

Associations

2

Offspring number

upin humans1

1 study
  1. Genetic susceptibility to complex diseases are associated with offspring number in humans (Positive associations for 87% of diseases with significant correlations).

    “87% of diseases with significant correlations showed positive associations with fertility.”

    HumansDiseases with significant genetic correlations with fertility

    Why do we get sick? Genetic evidence for evolutionary trade-offs between fertility, longevity, and disease

    medRxiv20 Jun 2025Preprint

Parental lifespan

downin humans1

1 study
  1. Genetic susceptibility to complex diseases are associated with parental lifespan in humans (Negative genetic correlations for 85% of diseases).

    “We found that 85% of diseases showed negative genetic correlations with longevity”

    HumansGenetic correlations across 62 complex diseases; parental lifespan used as a proxy for longevity

    Why do we get sick? Genetic evidence for evolutionary trade-offs between fertility, longevity, and disease

    medRxiv20 Jun 2025Preprint

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