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Free cholesterol to total lipid ratio in medium HDL

Biomarker

1 paper1 finding

  • Humans1

Effects

1

Alzheimer's disease risk

mediatesin humans1

1 study

  1. Free cholesterol to total lipid ratio in medium HDL mediates alzheimer's disease risk in humans (13.0% mediated; deleterious mediator).

    “the free cholesterol to total lipid ratio in medium high-density lipoproteins (HDL) emerged as a deleterious mediator, explaining 13.0% of the protective association between TAG(52:3) and AD.”

    HumansMediation of the protective association of TAG(52:3)

    Two blood fats linked to lower Alzheimer's disease risk

    Journal of Alzheimer's disease reports12 Jun 2026

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Journal of Alzheimer's Disease Reports

Two blood fats linked to lower Alzheimer's disease risk

An analysis of human genetic data suggested that other blood-fat measures may partly account for the associations with Alzheimer's disease.An analysis of human genetic data suggested that other blood-fat measures may partly account for the associations with Alzheimer's disease.

Mendelian randomisation in peopleMechanisms
Paper

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