There are 2 papers on frataxin in aging research: 1 observational study in people, 1 in animals.
- Humans1
- Animals1
Interventions
2Beta-hydroxybutyrate
upin human cells1
1 study
Beta-hydroxybutyrate
upin human cells1
Beta-hydroxybutyrate increases frataxin in human cells (FRDA).
“{beta}-hydroxybutyrate administration in FRDA iPSC-derived cardiomyocytes elevates frataxin levels and mitochondrial biogenesis markers”
CellsFRDAiPSC-derived cardiomyocyte
Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model
bioRxivPreprint
Fasting
upin mice1
1 study
Fasting
upin mice1
Fasting increases frataxin in mice (KIKO/OXCT1+/- mice).
“Fasting-which promotes ketosis-similarly increases frataxin levels and mitochondrial biogenesis markers in older KIKO/OXCT1+/- mice.”
AnimalsKIKO/OXCT1+/- mice
Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model
bioRxivPreprint
Latest
3 papers in 12 monthsbioRxiv
Ketosis rescues frataxin deficiency and corrects disease phenotypes in an FRDA animal model
Preprint: experiments in miceInterventions
Molecular Biomedicine
Autophagy activation by urolithin-a derivative UA-36 mitigates Friedreich's ataxia pathologies induced by frataxin deficiency
Experiments in miceInterventions
Nature
Cross-regulation of [2Fe-2S] cluster synthesis by ferredoxin-2 and frataxin
Experiments in fliesMechanisms
Biochimie
Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila
Experiments in fliesMechanisms
Frontiers in Cell and Developmental Biology
Cobalt chloride has beneficial effects across species through a hormetic mechanism
Experiments in wormsInterventions
The Journal of Clinical Investigation
Frataxin and endothelial cell senescence in pulmonary hypertension
CommentaryPulmonary hypertension