Frailty-related metabolomic signature score
1 paper4 findings
- Humans1
Effects
1Cardiovascular disease
mediatesin humans1
1 study
Cardiovascular disease
mediatesin humans1
Frailty-related metabolomic signature score mediates cardiovascular disease in humans (14.9%).
“Mediation analysis indicated that the metabolomic signature accounted for 14.9% of the association between frailty and overall CVD”
Humansassociation between frailty and overall CVDn = 95,770
The journals of gerontology. Series A, Biological sciences and medical sciences16 Feb 2026
Associations
3Stroke
upin humans1HR 1.45
1 study
Stroke
upin humans1HR 1.45
Frailty-related metabolomic signature score raises the risk of stroke in humans (HR 1.45, 95% CI 1.37-1.54).
“and stroke (HR = 1.45; 95% CI: 1.37-1.54).”
Humans13.81 yearsn = 95,770
The journals of gerontology. Series A, Biological sciences and medical sciences16 Feb 2026
Coronary heart disease
upin humans1HR 1.5
1 study
Coronary heart disease
upin humans1HR 1.5
Frailty-related metabolomic signature score raises the risk of coronary heart disease in humans (HR 1.50, 95% CI 1.41-1.61).
“CHD (HR = 1.50; 95% CI: 1.41-1.61)”
Humans13.81 yearsn = 95,770
The journals of gerontology. Series A, Biological sciences and medical sciences16 Feb 2026
Cardiovascular disease
upin humans1HR 1.44
1 study
Cardiovascular disease
upin humans1HR 1.44
Frailty-related metabolomic signature score raises the risk of cardiovascular disease in humans (HR 1.44, 95% CI 1.36-1.53).
“High metabolomic signature scores were significantly associated with increased risks of CVD (hazard ratio [HR] = 1.44; 95% confidence interval [CI]: 1.36-1.53)”
Humans13.81 yearsn = 95,770
The journals of gerontology. Series A, Biological sciences and medical sciences16 Feb 2026